Two sample MR report
LGALS2_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0708512 | 0.2274902 | 0.7758494 |
| Weighted median | 5 | 0.0201787 | 0.0081341 | 0.0131106 |
| Inverse variance weighted | 5 | 0.0201679 | 0.0067229 | 0.0027009 |
| Simple mode | 5 | 0.0197524 | 0.0105622 | 0.1348150 |
| Weighted mode | 5 | 0.0199030 | 0.0101619 | 0.1217512 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3339809 | 3 | 0.9535159 |
| Inverse variance weighted | 0.3836610 | 4 | 0.9837926 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0408042 | 0.1830683 | 0.8379344 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.36e-05 | 0 | TRUE | 0.4159689 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
